产品货号：
GS4831
中文名称：
重组人BAFF
英文名称：
Recombinant Human B Cell Activating Factor
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.2kDa,a single non-glycosylated polypeptide chain containing 153 amino acids.
储存条件：冷冻（-20℃）
概述
B-cell activating factor(BAFF),also known as Blys,TALL-1,TNAK,and zTNF4,is a TNF ligand superfamily member and has been designated TNFSF13B.Produced by macrophages,dendritic cells,and T lymphocytes,BAFF promotes the survival of B cells and is essential for B cell maturation.BAFF binds to three TNF receptor superfamily members:B-cell maturation antigen(BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor(TACI/TNFRSF13B)and BAFF receptor(BAFF R/BR3/TNFRSF 13C).These receptors are type III transmembrane proteins that lack a signal peptide.Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand,APRIL(a proliferation-inducing ligand),BAFF R selectively binds BAFF.The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain(CRD)and contains only a partial CRD with four cysteine residues.Human and mouse BAFF R share 56%a.a.sequence identity.BAFF R is highly expressed in spleen,lymph node and resting B cells.It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人BAFF，BAFF, Human，Recombinant Human B Cell Activating Factor
储存条件：冷冻（-20℃）
概述
B-cell activating factor(BAFF),also known as Blys,TALL-1,TNAK,and zTNF4,is a TNF ligand superfamily member and has been designated TNFSF13B.Produced by macrophages,dendritic cells,and T lymphocytes,BAFF promotes the survival of B cells and is essential for B cell maturation.BAFF binds to three TNF receptor superfamily members:B-cell maturation antigen(BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor(TACI/TNFRSF13B)and BAFF receptor(BAFF R/BR3/TNFRSF 13C).These receptors are type III transmembrane proteins that lack a signal peptide.Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand,APRIL(a proliferation-inducing ligand),BAFF R selectively binds BAFF.The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain(CRD)and contains only a partial CRD with four cysteine residues.Human and mouse BAFF R share 56%a.a.sequence identity.BAFF R is highly expressed in spleen,lymph node and resting B cells.It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a mouse splenocyte survival assay is 0.5-2μg/ml. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.0. |
| 内毒素 | Less than 1 EU/μg of rHuBAFF as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL |
相关搜索：重组人BAFF，BAFF, Human，Recombinant Human B Cell Activating Factor